Comprehensive Review of Dihydro‐2H‐pyrrol‐2‐one Derivatives

Abstract

Heterocyclic chemistry has emerged as a significant field with diverse applications in recent scenarios. Nitrogen‐containing heterocyclic compounds have garnered significant attention due to their unique physiological characteristics and extensive medicinal utility. Therefore, the dihydro‐2H‐pyrrol‐2‐one scaffold is a key skeleton for medicinal and pharmaceutical research due to its high bioavailability and wider synthetic applications. This study found that 1,5‐dihydro‐2H‐pyrrol‐2‐one scaffolds can be used in many ways. Thus, these scaffolds have been the subject of a lot of research in recent years, but preparation of the main core is harder because of their structure. This study covers the synthetic methods used over the past 15 years to synthesize substituted dihydro‐2H‐pyrrol‐2‐one derivatives through a variety of reaction approaches by utilizing hybrid catalyzing systems, including photocatalysis, electrocatalysis, alkaline catalysts, acid catalysts, organocatalysts, ionic liquid catalysts, nanocatalysts, heterogeneous or homogeneous transitional‐metal catalysis (including Cu, Pd, Ni, Ru, Co, Fe, Si, Pt, Zn, etc.), as well as the mechanism. This review will encourage the researchers to exploit wider catalytic applications for the synthesis of target compounds.