Contribution of oxidative stress to neurodegenerative disease

Contribution of oxidative stress to neurodegenerative disease

Paul A. Hyslop, from Arkley BioTek Indianapolis, details an ongoing specific research approach to identify, characterize, and validate physiologically relevant neuronal targets of H2O2 in designing therapeutics for neurodegenerative disease progression. The societal impact of dementia resulting from the major neurodegenerative diseases such as Alzheimer’s presents a growing and significant unmet medical need. (1) Various cellular metabolic and structural deficits, neuroinflammation, and oxidative stress are known to result in the progressive loss of vulnerable non-regenerative neurons. (2)