Correlation between levodopa equivalent daily dose (LEDD) and sleep quality in Parkinson’s disease patient as weighed by Parkinson’s disease sleep scale-2 (PDSS-2)

Parkinson’s disease (PD) is the most prevalent movement disorder that affects the central nervous system. The main non-motor symptoms of PD are sleep disturbances. One reason for sleep impairments in PD is the impact of dopaminergic medications. Given the variability in each patient’s medication regimen, a standardized measure like levodopa equivalent daily dose (LEDD) is used. The purpose of this observational cross-sectional analytical study is to determine the association between LEDD and sleep quality in PD patients, as weighed by the PD sleep scale-2. There are 50 participants in the walk-in patient and inpatient wards in Dr. Soetomo General Academic Hospital and Airlangga University Hospital Surabaya. Spearman analysis showed a non-significant result (P = 0.15). Bivariate analysis of anxiety against sleep quality revealed a significant relationship (P = 0.017). After performing a stratified analysis, there is no correlation (P = 0.863) in the non-anxiety group.