Deacylation of N‐Acylsulfonamides Mediated by Metal Triflimides

N‐Acylsulfonamides play a significant role in organic and medicinal chemistry. The N‐deacylation of N‐acylsulfonamides is an important transformation that releases the sulfonamide structural motif. Herein, a metal triflimide‐catalyzed nonhydrolytic method for the deacylation of N‐acylsulfonamides is presented. Commercially available metal triflimides reactive for the N‐deacylation include Cu(NTf2)2, Zn(NTf2)2, Mg(NTf2)2, Ce(NTf2)3, and La(NTf2)3. A range of N‐acyl groups, including acetyl, propionyl, butyryl, isobutyryl, octanoyl, benzoyl, 2‐phenylacetyl, and sterically hindered pivaloyl are readily deblocked efficiently. A variety of functional groups, such as halogeno, keto, nitro, cyano, ether, and carboxylate, are tolerated intact.