Wounds are physical injuries that result in an opening or break of the skin, the proper healing of wounds is essential for the restoration of disrupted anatomical continuity and disturbed functional status of the skin. Healing is complex and initiated in response to an injury that restores the function and integrity of damaged tissues. Nanostructured lipid carriers (NLCs) for dermal application can provide enhanced skin permeation. Naringenin belongs to the flavanone class of flavanoids and is abundantly present in citrus fruits. It has therapeutic interventions as antioxidant, anti-inflammatory, antidiabetic, and anticancer agents. But some drawbacks include poor solubility, fast metabolism and inadequate bioavailabilityhinder the application of flavanoids, which can be addressed through increased absorption, solubility and stability.The present study was aimed at formulating naringenin-loaded NLCs for reducing the skin irritation potential, increasing the drug loading capacity and prolonging the duration of action. Naringenin-loaded NLCs were prepared by hot melt microemulsion and hot melt probe sonication methods.The properties of the optimized NLCs such as morphology, size, Zeta potential, stability and Invitro drug release were investigated. Naringenin-loadedNLCs showed a sustained release pattern tested and were found to follow the Higuchi model of drug release. Stability studies indicated that the formulations stored at refrigeration and room temperature showed no noticeable differences in the drug content and release profilesIn vitro, after a period of 4 weeks. The results showed that the irritation potential of Naringenin was reduced, the drug loading was increased and the drug release was prolonged by the incorporationof naringenin into the NLCs.

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