Kentaro Shimizu, Haruhiko Hirata, Natsuko Tokuhira, Daisuke Motooka, Shota Nakamura, Akiko Ueda, Jotaro Tachino, Moe Koide, Akinori Uchiyama, Hiroshi Ogura, Jun Oda

Dysbiosis of gut microbiota in patients with severe COVID‐19

  • Industrial and Manufacturing Engineering
  • Materials Science (miscellaneous)
  • Business and International Management
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AbstractAimAltered gut microbiota has been proposed as one of the causes of exacerbation of severe acute respiratory syndrome coronavirus 2 (SARS‐CoV‐2/COVID‐19) from the perspective of the gut–lung axis. We aimed to evaluate gut microbiota in mechanically ventilated patients with COVID‐19 prior to using antibiotics.MethodsWe retrospectively selected for enrollment COVID‐19 patients who required mechanical ventilation on admission but who had not used antibiotics before admission to observe the influence of SARS‐Cov‐2 on gut microbiota. Fecal samples were collected serially on admission and were evaluated by 16S rRNA gene deep sequencing.ResultsThe phylum of Bacteroidetes decreased, and those of Firmicutes and Actinobacteria increased in COVID‐19 patients compared with those in healthy controls (p < 0.001). The main commensals of Bacteroides, Faecalibacterium, and Blautia at the genus level were significantly decreased in the COVID‐19 patients, and opportunistic bacteria including Corynebacterium, Anaerococcus, Finegoldia Peptoniphilus, Actinomyces, and Enterococcus were increased (p < 0.001). α‐Diversity and β‐diversity in COVID‐19 patients significantly changed compared with those in the healthy controls.ConclusionThe commensal gut microbiota were altered, and opportunistic bacteria increased in patients with severe COVID‐19 who required mechanical ventilation on admission.

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