DOI: 10.3390/info15030163 ISSN: 2078-2489

E-MuLA: An Ensemble Multi-Localized Attention Feature Extraction Network for Viral Protein Subcellular Localization

Grace-Mercure Bakanina Kissanga, Hasan Zulfiqar, Shenghan Gao, Sophyani Banaamwini Yussif, Biffon Manyura Momanyi, Lin Ning, Hao Lin, Cheng-Bing Huang
  • Information Systems

Accurate prediction of subcellular localization of viral proteins is crucial for understanding their functions and developing effective antiviral drugs. However, this task poses a significant challenge, especially when relying on expensive and time-consuming classical biological experiments. In this study, we introduced a computational model called E-MuLA, based on a deep learning network that combines multiple local attention modules to enhance feature extraction from protein sequences. The superior performance of the E-MuLA has been demonstrated through extensive comparisons with LSTM, CNN, AdaBoost, decision trees, KNN, and other state-of-the-art methods. It is noteworthy that the E-MuLA achieved an accuracy of 94.87%, specificity of 98.81%, and sensitivity of 84.18%, indicating that E-MuLA has the potential to become an effective tool for predicting virus subcellular localization.

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