DOI: 10.1039/d4ra02790f ISSN: 2046-2069
Easy one-pot synthesis of multifunctionalized indole–pyrrole hybrids as a new class of antileishmanial agents
Vittorio Ciccone, Aurora Diotallevi, Miriam Gómez-Benmansour, Sara Maestrini, Fabio Mantellini, Giacomo Mari, Luca Galluzzi, Simone Lucarini, Gianfranco FaviA chemoselective one-pot synthesis of indole–pyrrole hybrids has been developed. The new hybrids were phenotypically screened for efficacy against L. infantum promastigotes. Compound 3d was the most active with IC50 = 9.6 μM and a selectivity index of 5.