Rhea Mehta, Marc Hochberg, Michelle Shardell, Alice Ryan, Yu Dong, Brock A. Beamer, Jason Peer, Elizabeth A. Stuart, Megan Schuler, Joseph J. Gallo, Alan M. Rathbun

Evaluation of Dynamic Effects of Depressive Symptoms on Physical Function in Knee Osteoarthritis

  • Rheumatology
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ObjectiveTo assess how changes in depressive symptoms influence physical function over time among those with radiographic knee OA.MethodsParticipants from the Osteoarthritis Initiative (OAI) with radiographic knee OA (n=2,212) and complete data were identified at baseline. Depressive symptoms were assessed as a time‐varying score at baseline and the first three annual follow‐up visits using the Center for Epidemiological Studies Depression (CES‐D) Scale. Physical function was measured at the first four follow‐up visits using 20‐meter gait speed meters per second (m/s). Two marginal structural models (MSMs) were fit: one assessing the main effect of depressive symptoms on gait speed and another assessing time‐specific associations.ResultsTime‐adjusted results indicated that higher CES‐D scores were significantly associated with slower gait speed (‐0.0048; 95% CI: ‐0.0082, ‐0.0014), and time‐specific associations of CES‐D were largest during the first follow‐up interval (‐0.0082; 95% CI: ‐0.0128, ‐0.0035). During subsequent follow‐up time points, the influence of depressive symptoms on gait speed diminished.ConclusionThe negative effect of depressive symptoms on physical function may decrease over time as knee OA progresses.

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