George R. Thompson, Jeffrey D. Jenks, John W. Baddley, James S. Lewis, Matthias Egger, Ilan S. Schwartz, Johannes Boyer, Thomas F. Patterson, Sharon C.-A. Chen, Peter G. Pappas, Martin Hoenigl

Fungal Endocarditis: Pathophysiology, Epidemiology, Clinical Presentation, Diagnosis, and Management

  • Infectious Diseases
  • Microbiology (medical)
  • Public Health, Environmental and Occupational Health
  • General Immunology and Microbiology
  • Epidemiology
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Fungal endocarditis accounts for 1% to 3% of all infective endocarditis cases, is associated with high morbidity and mortality (>70%), and presents numerous challenges during clinical care. Candida spp. are the most common causes of fungal endocarditis, implicated in over 50% of cases, followed by Aspergillus and Histoplasma spp. Important risk factors for fungal endocarditis include prosthetic valves, prior heart surgery, and injection drug use.

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