DOI: 10.1093/braincomms/fcae096 ISSN: 2632-1297

Hippocampal hyperphosphorylated tau-induced deficiency is rescued by L-type calcium channel blockade

Chelsea A Crossley, Tamunotonye Omoluabi, Sarah E Torraville, Sarah Duraid, Aida Maziar, Zia Hasan, Vishaal Rajani, Kanae Ando, Johannes W Hell, Qi Yuan
  • Neurology
  • Cellular and Molecular Neuroscience
  • Biological Psychiatry
  • Psychiatry and Mental health
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Abstract

Aging and Alzheimer’s disease are associated with chronic elevations in neuronal calcium influx via L-type calcium channels. The hippocampus, a primary memory encoding structure in the brain, is more vulnerable to calcium dysregulation in Alzheimer’s disease. Recent research has suggested a link between L-type calcium channels and tau hyperphosphorylation. However, the precise mechanism of L-type calcium channel-mediated tau toxicity is not understood.

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