Hyalinizing clear cell carcinoma of the left main bronchus diagnosed with Ewing sarcoma breakpoint region 1::activating transcription factor 1 fusion: A case report
Riken Kawachi, Hiyo Obikane, Daisuke Satoh, Mie Shimamura, Toshitaka Nagao, Shinobu Masuda, Hiroyuki Sakurai- General Earth and Planetary Sciences
- General Environmental Science
Rationale:
Hyalinizing clear cell carcinoma (HCCC) of the bronchus is extremely rare. In addition, its rarity makes an accurate histological diagnosis difficult. Herein, we report a case of HCCC in the left main bronchus diagnosed by the detection of
Patient concerns:
A 56-year-old woman presented with a tumor obstructing the left main bronchus on physical examination computed tomography. A bronchoscopic biopsy confirmed a malignant tumor but did not provide a definitive diagnosis.
Interventions:
Sleeve resection of the left main bronchus was performed. The intraoperative frozen section was negative for cancer in both the proximal and distal bronchial stumps.
Diagnosis:
General immunohistochemical staining was performed, and mucoepidermoid carcinoma and HCCC were suspected. RT-PCR revealed positive results for
Outcomes:
The patient was discharged without any postoperative complications. Sixty-five months have passed since surgery, and no cancer recurrence has been observed.
Lessons:
Although hematoxylin and eosin staining and immunostaining alone were not sufficient to distinguish HCCC from mucoepidermoid carcinoma and other malignant tumors, adding genetic testing for