Life expectancy and death pattern associated with systemic lupus erythematosus diagnosis in Brazil between 2000 and 2019
Edgard Torres dos Reis-Neto, Odirlei Andre Monticielo, Milena Daher, Flávia Lopes, Daniel Angrimani, Evandro Mendes Klumb- Rheumatology
Objectives
to evaluate the main factors associated with mortality and determine the life expectancy of SLE patients between 2000 and 2019 years in Brazil.
Methods
death data related to SLE available in the Brazilian Unified Health System (SUS) (DATASUS) were evaluated in all Brazilian states. Three groups of death causes potentially associated from SLE were evaluated: cardiovascular and kidney diseases and infections.
Results
The main causes of death associated with SLE were infection and kidney disease. Most SLE patients died between 19 and 50 years of age. Deaths associated with kidney disease were proportionally higher than in the general population with progressive decrease during the period. Instead, there have been an increase in the proportion of deaths due to infections both in SLE and in the general population.
Conclusions
SLE patients presented higher mortality compared to the general population matched for sex and age and the main causes associated with death were infection and kidney disease. Public health policies that promote early diagnosis, treatment and prevention of damage are necessary to reduce morbidity and mortality in SLE patients.