DOI: 10.37990/medr.1316792 ISSN:

MATERNAL BISPHENOL-A'NIN SIÇAN BÖBREK GELİŞİMİ ÜZERİNDEKİ ETKİSİNİN İNCELENMESİ

Dilek MEYDAN, Semih TAN, Saim ÖZDAMAR, Hülya ÇETİN
  • Colloid and Surface Chemistry
  • Physical and Theoretical Chemistry
Show PDF Cite
Bisphenol-A is an estrogenic chemical used today in the production of epoxy resin and as an additive in other non-polymer plastics. Due to the widespread use of BPA today, human exposure is inevitable. This exposure causes harmful effects on various body systems. The aim of this study is to investigate the effects on the development of the kidneys of the offspring of mother rats exposed to BPA during pregnancy and lactation, as a result of the offspring being exposed to BPA through the placenta and milk. In this study, 13 adult Wistar albino female rats were divided into 3 groups. In Group 1 (Control group), rats were only administered 1 ml/kg/day corn oil intraperitoneally. Group 2 (25 mg BPA group) rats were administered 25 mg/kg/day BPA; Group 3 (50 mg group) rats were administered 50 mg/kg/day BPA intraperitoneally for 5 weeks. At the end of the experiment, the intracardiac blood and kidney tissues of the offspring rats were taken and examined for urea, total protein, creatinine, TAS, TOS, MDA values. At the end of the study, it was determined that BPA increased serum urea, creatinine and total protein levels, induced the formation of reactive oxygen species causing oxidative damage in kidney tissue, and caused serious structural damages such as narrowing in the Bowman's space of the renal corpuscle in the kidneys of the offspring rats, dilation in the proximal, distal tubules and collecting ducts, cell loss in tubular epithelium, and vacuolation.

More from our Archive