Moxifloxacin monotherapy for treatment of uncomplicated pelvic inflammatory disease: A systematic review and meta‐analysis with trial sequential analysis of randomized controlled trials
Feng Chen, Qin Dong, Weilan Hong, Jing Zhao, Yingran Li- Pharmacology (medical)
- Epidemiology
Abstract
Purpose
The aim of this study was to evaluate the efficacy and safety of moxifloxacin monotherapy for the treatment of uncomplicated pelvic inflammatory disease (uPID).
Methods
The literatures from PubMed, ScienceDirect, Google Scholar, Cochrane library and the
Results
A total of four RCTs that enrolled 3201 women patients with uPID were included. In the per‐protocol populations, no significant difference was observed between patients given moxifloxacin and those given other antibiotics with regard to CCR at test‐of‐cure (TOC) (2485 patients, odds ratio [OR] = 0.84, 95% confidence interval [CI] 0.68–1.04, p = 0.12). Similarly, there was no statistically significant difference between patients given moxifloxacin and those given other antibiotics in terms of BSR at TOC (471 patients, OR = 1.17, 95% CI 0.70–1.96, p = 0.56) in the microbiologically valid population. However, drug‐related AEs occurred less frequently with moxifloxacin than with other antibiotics (2973 patients, OR = 0.74, 95% CI 0.64–0.86, p < 0.0001), especially gastrointestinal AEs (2973 patients, OR = 0.59, 95% CI 0.47–0.74, p < 0.00001).
Conclusions
In the treatment of uPID, moxifloxacin monotherapy can achieve similar efficacy as other combination therapy regimens. Moreover, moxifloxacin had a better safety profile than that of comparators. Based on its additional advantages (i.e., better safety profile, no dosage adjustment and better compliance), moxifloxacin may be a more fascinating option compared with the currently used regimens.