DOI: 10.1002/ejoc.202300765 ISSN:
One‐Carbon Homologation of α,β‐Unsaturated Aldehydes: Access to α‐Tertiary β,γ‐Unsaturated Aldehydes
Arnaud Delbrassinne, Boris Junior Takam Mba, Laurent Collard, Raphael Robiette- Organic Chemistry
- Physical and Theoretical Chemistry
An efficient protocol for the synthesis of enolizable α‐substituted β,γ‐unsaturated aldehydes is reported. The developed strategy involves two steps, epoxidation and Meinwald rearrangement, to result in a one‐carbon homologation of α,β‐unsaturated aldehydes enabling the insertion of a CHR unit