DOI: 10.4103/ayu.ayu_366_21 ISSN: 0974-8520
Pharmacokinetic analysis of Tulasi Swarasadi Taila administered through Nasya (therapeutic nasal administration) and oral route in albino rats
Tarun Kumar, Balaji Panigrahi, Mukesh Nariya, Anup Thakar
Introduction:
Tulasi Swarasadi Taila (medicated oil) is a medicated oil that has been indicated for Nasya (therapeutic nasal administration) and oral administration to alleviate diseases like Pratishyaya (allergic rhinitis). The drug has been widely used through intranasal and oral routes for the management of various diseases. However, its pharmacokinetic analysis has been unexplored which urges improved methods of standardization.
Aim:
The study was conducted to understand the pharmacokinetic profile of Tulasi Swarasadi Taila administered through Nasya (nasal) and oral routes in albino rats.
Materials and methods:
Tulasi Swarasadi Taila was administered in a single dose of 0.54 ml/kg through the Nasya route and 1.8 ml/kg through the oral route to the healthy Wistar strain albino rats. The serum was collected at different time intervals and estimated by gas chromatography coupled with mass spectroscopy analysis for the separation of volatile substances and identification of the unknown compounds.
Results:
There were arachidic acid, icosamethylcyclodecasiloxane, tridecane, eugenol, and many other compounds present in the serum after administration of Tulasi Swarasadi Taila, that were absent initially at the baseline.
Conclusion:
Tulasi Swarsadi Taila is absorbed in systemic circulation from oral and Nasya routes in rats. However, the pattern of the presence of phytoconstituents in serum varied at different time intervals in the cases of both routes of drug administration in albino rats.