Mancin Stefano, Mazzoleni Beatrice

Probiotics as adjuvant therapy in the treatment of Allergic Rhinitis.

  • Pharmacology (medical)
  • Pharmacology, Toxicology and Pharmaceutics (miscellaneous)
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Introduction: Allergic rhinitis is a symptomatic disorder of the nasal passages, induced by a hyper-activation of the immune system towards allergens present in the air, resulting in an immunoglobulin E (IgE) mediated response. Several studies have shown a preventive role of different probiotic strains in the treatment of various autoimmune diseases, in the modulation of the immune system and the production of antimicrobial peptides, favoring a better modulation of the inflammatory response. Methodology: Through a systematic review of the literature, carried out according to the PRISMA statement guidelines, 16 articles were deemed eligible for our review. Results: The data found in the literature regarding the administration of probiotic strains as adjuvant therapy in the treatment of allergic rhinitis and associated symptoms showed an improvement in the quality of life, reduction of allergic symptoms and a better modulation of the inflammatory and antibody response. Conclusions: the results of our review demonstrate the positive effects of supplementing with probiotics as an adjuvant therapy in the treatment of allergic rhinitis. However, further studies are needed due to the evident heterogeneity of the trials analyzed and, which include a greater number of subjects enrolled in order to be able to confirm the results obtained.

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