DOI: 10.1002/ejoc.202300823 ISSN:
Rhodium‐Catalysed Selective C‐H Allylation of 1H‐Indazoles with Vinylethylene Carbonate: Easily Introducing Allylic Alcohol
Xiang Zhao, Junwei Huang, Yadong Feng, Xiuling Cui- Organic Chemistry
- Physical and Theoretical Chemistry
An efficient rhodium(III)‐catalysed C‐H activation of 3‐aryl‐1‐H‐indazoles with easily available vinylethylene carbonate has been reported. A series of allyl alcohol substituted 3‐aryl‐1‐H‐indazoles were obtained with broad functional groups tolerance and favourable stereoselectivity. Notably, C‐H and C‐O bonds were selectively activated in “one pot” manner, releasing CO2 as the sole by‐product and avoiding external oxidant. This protocol provides a powerful approach for the post stage C‐H allylation of indazole‐based substrates.