DOI: 10.1002/slct.202301735 ISSN:
Ruthenium‐Catalyzed Synthesis of Macrocyclic Isoquinolines and Isoquinolones via a C−H/N−H Annulations Reaction
Palanivelu Gurumurthy, Rajini Raja, Natarajan Arumugam, Abdulrahman I. Almansour, Raju Suresh Kumar, Karthikeyan Perumal, Kanniyappan Parthasarathy- General Chemistry
Abstract
An Ru(II)‐catalyzed C−H annulations of oximes and N‐methoxybenzamides with bridged alkyne is described. This method is useful for the efficient synthesis of various macrocyclic isoquinolines and isoquinolones in good to moderate yields. A possible mechanism, involving a key five‐membered metallacycle intermediate, alkyne insertion followed by reductive elimination to give a final annulated product has been proposed.