GRADE pearls and pitfalls—Part 1: Systematic reviews and meta‐analyses
Zainab Al Duhailib, Anders Granholm, Waleed Alhazzani, Simon Oczkowski, Emilie Belley‐Cote, Morten Hylander Møller - Anesthesiology and Pain Medicine
- General Medicine
Abstract
Background
The Grading of Recommendation, Assessment, Development and Evaluation (GRADE) approach is used to assess the certainty of evidence in systematic reviews and meta‐analyses.
Methods
We describe how the GRADE approach is used in systematic reviews and meta‐analyses, including key points and examples. This overview is aimed at clinicians and researchers who are, or plan to be, involved in the development or assessment of systematic reviews with meta‐analyses using GRADE.
Results
We outline how the certainty of evidence is assessed, how the evidence is summarized using GRADE evidence profiles or summary of findings tables, how the results are communicated, and we discuss challenges, advantages, and disadvantages with using GRADE.
Conclusions
This overview aims to provide an overview of how GRADE is used in systematic reviews and meta‐analyses, and may be used by systematic review developers, methodologists, and evidence end‐users.