DOI: 10.1126/sciimmunol.adj3102 ISSN:
Sinking while you swim: A dual role for CCR7 in leukocyte migration
Hannah Donnelly, Elena Mandrou, Robert Insall- General Medicine
- Immunology
The CCR7 receptor allows dendritic cells to sense the chemokine CCL19. It also depletes CCL19 from the environment by endocytosis, leading to local gradients that can steer cells accurately and robustly through tissues, even over long distances (see related Research Article by Alanko et al .).