Study of Relationship between Stool Lactobacillus acidophilus and Grave’s Disease in a Sample of Egyptian Population
Inas Mohammed Sabry, Laila Mahmoud Ali Hendawy, Hanan Mahmoud Ali, Aya Madboly Helmy- General Medicine
Abstract
Background
Graves’ disease is an autoimmune disease that leads to a generalized overactivity of the entire thyroid gland (hyperthyroidism). When unrecognized, It impacts negatively on quality of life and poses serious risks of psychosis, tachyarrhythmia and cardiac failure. It affect 0.5% of the population in the US, and represents 50-80% of cases of hyperthyroidism. It occurs more commonly amongst women, smokers and patients with other autoimmune diseases or a family history of thyroid autoimmunity.
Aim of the Work
The study is aimed to study the relationship between stool lactobacillus acidophilus and grave’s disease in a sample of Egyptian population
Patients and Methods
This study is a case control study, was carried out at Endocrine outpatient clinic at Ain Shams University Hospital, on 60 Egyptian patients age 25-40 years old, from September 2020 till March 2021.
Results
Among group1A, 5(25%) were 25 -30 years old, 6(30%) were 30 – 35 years old, 9(45%) were ≥ 35 years old, the mean of ages was 32.75 (±4.94 SD) with range (25.0 – 40.0), there were 5(25%) males, 15(75%) females, the mean of duration of the disease was 2.95(±2.14 SD) with range (1.0 – 7.0). Among group 1B, 8(40%) were 25 -30 years old, 5(25%) were 30 – 35 years old, 7(35%) were ≥ 35 years old, the mean of ages was 31.90(±4.69 SD) with range (26.0 – 40.0), there were 3(15%) males, 17(85%) females, the mean of duration of the disease was 3.25(±2.02 SD) with range (1.0 – 7.0). Among total cases of group 1, 13(32%) were 25 -30 years old, 11(27.5%) were 30 – 35 years old, 16(40%) were ≥ 35 years old, the mean of ages was 32.33(±4.77 SD) with range (25.0 – 40.0), there were 8(20%) males, 32(80%) females, the mean of duration of the disease was 3.10 (±2.06 SD) with range (1.0 – 7.0).
Conclusion
Stool Lactobacillus acidophilus PCR count was insignificantly different between studied groups, which may show no relationship of lactobacillus with graves’ disease. so, further studies are needed to determine correlation or causation of this relationship.