Successful use of eculizumab in immediate ANCA vasculitis recurrence in a pediatric kidney transplant
Caitlin G. Peterson, Rachel L. Jackson - Transplantation
- Pediatrics, Perinatology and Child Health
Abstract
Background
Kidney transplantation is an acceptable therapy end‐stage kidney disease secondary to antineutrophil cytoplasmic antibody‐associated vasculitis with risk of disease recurrence ranging from 3% to 17%. Standard posttransplant immunosuppression is the mainstay of therapy after recurrence. Recently, new medications focused on complement regulation and avoidance of steroids have been shown to be effective in treating antineutrophil cytoplasmic antibody (ANCA) vasculitis with no studies in the pediatric population.
Methods
We report a 5‐year‐old patient with immediate recurrence of positive myeloperoxidase (MPO)‐ANCA vasculitis after deceased donor kidney transplant and the novel use of eculizumab to salvage the graft.
Results
Eculizumab and transition to ravulizumab has been successful in improving graft function and maintenance of disease remission after immediate MPO‐ANCA vasculitis recurrence posttransplant.
Conclusions
Complement inhibitors may be used in addition to standard immunosuppression postkidney transplant in a pediatric patient with MPO‐ANCA vasculitis recurrence without higher rates of infections.