Supramolecular Nano‐assembly of Caffeate‐Strengthened Phenylboronic Ester with Multi‐step Ros Scavenging Ability for Targeted Therapy of Acute Kidney Injury

Abstract

Acute kidney injury (AKI) is a life‐threatening complication with a considerable occurrence among patients. AKI is typically accompanied by an elevation in reactive oxidative species (ROS) in renal tissues, which is the main contributor to kidney damage. Herein, a supramolecular nano‐assembly (Ser‐HPEC) containing an ethyl caffeate‐strengthened phenylboronic ester with ROS‐triggered antioxidative ability was proposed for AKI‐targeted therapy. Nano‐assemblies can rapidly accumulate in the ischemia‐reperfusion‐injured kidney via kidney the injury molecule‐1 (Kim‐1)‐mediated homing ability of L‐serine. By consuming pathological levels of ROS, two different antioxidants, ethyl caffeate (EC) and 4‐hydroxybenzyl alcohol (HBA), were spontaneously released from a single module to relieve oxidative stress and diminish acute inflammation in injured renal tissue. The multistep ROS scavenging strategy combined with a precise targeting capability endowed the aforementioned nano‐assembly with effectiveness in preserving the integrity and functions of the injured kidney, providing new inspiration for the treatment of inflammatory diseases, including AKI.

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