AbstractBackgroundGS‐441524 has been successfully used to treat feline infectious peritonitis (FIP) in cats. However, the use of its prodrug, remdesivir, in combination with a PO GS‐441524 containing product for the treatment of FIP has not yet been described.ObjectivesDescribe treatment protocols, response to treatment and outcomes in cats with FIP treated with a combination of PO GS‐441524 and injectable remdesivir.AnimalsThirty‐two client‐owned cats diagnosed with effusive or non‐effusive FIP including those with ocular and neurological involvement.MethodsCats diagnosed with FIP at a single university hospital between August 2021 and July 2022 were included. Variables were recorded from time of diagnosis, and subsequent follow‐up information was obtained from the records of referring veterinarians. All surviving cats were observed for the entire 12‐week treatment period.ResultsCats received treatment with different combinations of IV remdesivir, SC remdesivir, and PO GS‐441524 at a median (range) dosage of 15 (10‐20) mg/kg. Clinical response to treatment was observed in 28 of 32 cats (87.5%) in a median (range) of 2 (1‐5) days. Twenty‐six of 32 cats (81.3%) were alive and in clinical and biochemical remission at the end of the 12‐week treatment period. Six of 32 cats (18.8%) died or were euthanized during treatment with 4 of the 6 cats (66%) dying within 3 days of starting treatment.ConclusionsWe describe the effective use of injectable remdesivir and PO GS‐441524 for the treatment of FIP in cats. Success occurred using different treatment protocols and with different presentations of FIP including cats with ocular and neurological involvement.

More from our Archive

• DOI: 10.1177/03009858231186737 2023

  Multipathogen infections and multifactorial pathogenesis involved in noble pen shell (<i>Pinna nobilis</i>) mass mortality events: Background and current pathologic approaches

  Francesca Carella, Dušan Palić, Tomislav Šarić, Ivan Župan, Bartolomeo Gorgoglione, Patricia Prado, Karl B. Andree, Ioannis A. Giantsis, Basile Michaelidis, Athanasios Lattos, John A. Theodorou, Juan Luis Barja Perez, Sergio Rodriguez, Fabio Scarpa, Marco Casu, Elisabetta Antuofermo, Daria Sanna, Domenico Otranto, Rossella Panarese, Carmelo Iaria, Fabio Marino, Gionata De Vico

• DOI: 10.1111/jvim.16803 2023

  Outcomes of treatment of cats with feline infectious peritonitis using parenterally administered remdesivir, with or without transition to orally administered <scp>GS</scp>‐441524

  Sally J. Coggins, Jacqui M. Norris, Richard Malik, Merran Govendir, Evelyn J. Hall, Benjamin Kimble, Mary F. Thompson

• DOI: 10.1111/jvim.16804 2023

  Thirty‐two cats with effusive or non‐effusive feline infectious peritonitis treated with a combination of remdesivir and GS‐441524

  Jodie Green, Harriet Syme, Sarah Tayler

• DOI: 10.3390/ani13132214 2023

  An Ultrasound-Guided Latero-Ventral Approach to Perform the Quadratus Lumborum Block in Dog Cadavers

  André Marchina-Gonçalves, Francisco G. Laredo, Francisco Gil, Marta Soler, Amalia Agut, José Ignacio Redondo, Eliseo Belda

• DOI: 10.3390/ani13132173 2023

  The Role of Brown Adipose Tissue and Energy Metabolism in Mammalian Thermoregulation during the Perinatal Period

  Cécile Bienboire-Frosini, Dehua Wang, Míriam Marcet-Rius, Dina Villanueva-García, Angelo Gazzano, Adriana Domínguez-Oliva, Adriana Olmos-Hernández, Ismael Hernández-Ávalos, Karina Lezama-García, Antonio Verduzco-Mendoza, Jocelyn Gómez-Prado, Daniel Mota-Rojas

• DOI: 10.3390/ani13142337 2023

  Molecular Characterization and Antimicrobial Susceptibilities of Corynebacterium pseudotuberculosis Isolated from Caseous Lymphadenitis of Smallholder Sheep and Goats

  Hend M. El Damaty, Azza S. El-Demerdash, Norhan K. Abd El-Aziz, Sarah G. Yousef, Ahmed A. Hefny, Etab M. Abo Remela, Asmaa Shaker, Ibrahim Elsohaby

• DOI: 10.3390/ani13142311 2023

  Non-Invasive Biomarkers in Saliva and Eye Infrared Thermography to Assess the Stress Response of Calves during Transport

  Mariana Caipira Lei, Luís Félix, Ricardo Cardoso, Sandra Mariza Monteiro, Severiano Silva, Carlos Venâncio

• DOI: 10.3390/ani13142296 2023

  Net Energy Value of a Cassava Chip Ration for Lactation in Holstein–Friesian Crossbred Dairy Cattle Estimated by Indirect Calorimetry

  Thidarat Gunha, Kanokwan Kongphitee, Bhoowadol Binsulong, Kritapon Sommart

• DOI: 10.1111/vco.12922 2023

  The second‐generation curcumin analogue <scp>RL71</scp> elicits <scp>G2</scp>/<scp>M</scp> cell cycle arrest and apoptosis in canine osteosarcoma cells

  Barnaby Kelly, Douglas Thamm, Rhonda J. Rosengren

• DOI: 10.3390/ani13142247 2023

  Handling and Training of Wild Animals: Evidence and Ethics-Based Approaches and Best Practices in the Modern Zoo

  Sabrina Brando, Max Norman