Dieter Schrenk, Ashley Allemang, Jörg Fahrer, Henrik Harms, Xilin Li, Ge Lin, Catherine Mahony, Patrick Mulder, Ad Peijnenburg, Stefan Pfuhler, Ans Punt, Hartwig Sievers, John Troutman, Frances Widjaja

Toxins in Botanical Drugs and Plant-derived Food and Feed – from Science to Regulation: A Workshop Review

  • Organic Chemistry
  • Complementary and alternative medicine
  • Drug Discovery
  • Pharmaceutical Science
  • Pharmacology
  • Molecular Medicine
  • Analytical Chemistry
Save to CiteDrive Show PDF

AbstractIn September 2022, the 3rd International Workshop on pyrrolizidine alkaloids (PAs) and related phytotoxins was held on-line, entitled ʼToxins in botanical drugs and plant-derived food and feed – from science to regulationʼ. The workshop focused on new findings about the occurrence, exposure, toxicity, and risk assessment of PAs. In addition, new scientific results related to the risk assessment of alkenylbenzenes, a distinct class of herbal constituents, were presented. The presence of PAs and alkenylbenzenes in plant-derived food, feed, and herbal medicines has raised health concerns with respect to their acute and chronic toxicity but mainly related to the genotoxic and carcinogenic properties of several congeners. The compounds are natural constituents of a variety of plant families and species widely used in medicinal, food, and feed products. Their individual occurrence, levels, and toxic properties, together with the broad range of congeners present in nature, represent a striking challenge to modern toxicology. This review tries to provide an overview of the current knowledge on these compounds and indicates needs and perspectives for future research.

Need a simple solution for managing your BibTeX entries? Explore CiteDrive!

  • Web-based, modern reference management
  • Collaborate and share with fellow researchers
  • Integration with Overleaf
  • Comprehensive BibTeX/BibLaTeX support
  • Save articles and websites directly from your browser
  • Search for new articles from a database of tens of millions of references
Try out CiteDrive

More from our Archive