Hemani Yadav, Jinkala Sree Rekha, Smita Kayal, Prem Ramasubramani

UTILITY OF NEUTROPHIL LYMPHOCYTE RATIO (NLR) AND PLATELET LYMPHOCYTE RATIO (PLR) IN PATIENTS WITH BENIGN BREAST DISEASE AND CARCINOMA BREAST.

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Background:Inammation has an important role to play in tumor progression and dissemination. Neutrophil lymphocyte ratio (NLR) and Platelet Lymphocyte Ratio (PLR) can reect this inammatory state and predict the tumor behavior. We studied utility of NLR and PLR in differentiating between a. Benign breast disease and Carcinoma breast b. Non-metastatic and metastatic breast carcinoma. Methods: Retrospective analysis of clinic-pathological data of patients with benign breast disease and Carcinoma breast in a tertiary care centre in South India for a period of six months was done. Independent T test was used to nd out, if NLR and PLR can differentiate between a. Benign breast diseases and Carcinoma Breast b. Carcinoma breast with and without metastasis and c. Carcinoma breast with local and distant metastasis. Receiver operative characteristic curve (ROC) was used to nd the cut-off NLR and PLR between the groups as mentioned above. Results: Forty four cases of benign breast disease and 84 carcinoma breast cases were retrospectively analyzed. PLR was able to differentiate between benign breast disease and carcinoma breast with cut-off of 93.5 with 71% sensitivity. The optimal cut-off for NLR and PLR to differentiate local and distant metastasis was 1.9 and PLR 105.9 respectively. Conclusion: PLR was able to differentiate between benign and malignant breast diseases. NLR showed increasing trend and signicant difference in non- metastatic, local & distant metastasis cases of carcinoma breast.

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