Yellow leaf green tea modulates AMPK /ACC /SREBP1c signaling pathway and gut microbiota in high‐fat diet‐induced mice to alleviate obesity
Baoming Tian, Yizhu Pan, Xue Zhou, Yuezhi Jiang, Xiangchun Zhang, Xudong Luo, Kai Yang - Nutrition and Dietetics
- Agronomy and Crop Science
- Food Science
- Biotechnology
ABSTRACT
Background
Yellow leaf green tea (YLGT) is a new variety of Camellia sinensis (L.) O. Ktze, which has yellow leaves and the unique qualities of ‘three green through three yellow’. This study aimed to investigate the anti‐obesity effect of YLGT in mice fed a high‐fat diet (HFD) and to explore the potential mechanisms by regulating the AMPK/ACC/SREBP1c signaling pathways and gut microbiota.
Results
The results showed that YLGT aqueous extract reduced body weight, hepatic inflammation, fat accumulation and hyperlipidemia in HFD‐induced C57BL/6J mice, and accelerated energy metabolism, reduced fat synthesis, and suppressed obesity by activating the AMPK/CPT‐1α signaling pathway and inhibiting the FAS/ACC/SREBP‐1c signaling pathway. Fecal microbiota transplantation experiment further confirmed that the alteration of gut microbiota, e.g., increasing unclassified_Muribaculaceae and decreasing Colidextribacter, might be an important cause of YLGT water extract inhibiting obesity.
Conclusion
In conclusion, YLGT has a broad application prospect in the treatment of obesity and the development of anti‐obesity function beverages.
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